UK Biobank: opportunities for cardiovascular research.

Fitness, Physical Activity, And Cardiovascular Disease: Longitudinal And Genetic Analyses In The UK Biobank Study

The Significance of Biobanking in the Sustainability of Biomedical Research: A Review

Biobank, defined as a functional unit for facilitating and improving research by storing biospecimen and their accompanying data, is a key resource for advancement in life science. The history of biobanking goes back to the time of archiving pathology samples. Nowadays, biobanks have considerably improved and are classified into two categories: diseased-oriented and population-based biobanks. U...

Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches

UK Biobank is a prospective cohort study with 500,000 participants aged 40 to 69. Recently an enhanced imaging study received funding. Cardiovascular magnetic resonance (CMR) will be part of a multi-organ, multi-modality imaging visit in 3-4 dedicated UK Biobank imaging centres that will acquire and store imaging data from 100,000 participants (subject to successful piloting). In each of UK Bio...

UK Biobank: a model for public engagement?

Whilst in other applications of genetic technology the public debate has begun only when a piece of research has been completed, public consultations on biobanking began in 2000, before the funding for UK Biobank was even agreed, and have continued throughout its development. UK Biobank has obvious attractions for the British public. It is being set up specifically as a resource for research in...

Genotyping Technologies and Applications in the Era of Precision Medicine

Over the past decade, genotyping technologies have revolutionized the genomic research field by providing cost-effective genotyping of tens of thousands to millions of genetic markers at population scale. That became the driving force behind genome-wide association studies. The price of a genotyping chip with ~1 million variants is now less than $50. We now see large biobank studies with genoty...